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Oxygen Sensing an overview ScienceDirect Topics ~ Cellular oxygen sensing takes place through molecules that interact with oxygen and generate a signal that can be used as a measure of the oxygen concentration In response to that signal the cells alter their properties and⧸or generate extracellular signals that can be “read” by other cells and tissue
Potential Utility of Tissue Oxygen Sensors in Perfusion ~ The Lumee Oxygen Platform Profusa Inc has been developed to provide a method of monitoring subcutaneous tissue oxygen in the body The technology is based on the principles of optical spectroscopy and phosphorescence quenching of metalloporphyrins which are commonly used in medical and research applications
Oxygen Sensing in Tissues Helmut Acker 9783642834462 ~ Oxygen Sensing in Tissues Helmut Acker on FREE shipping on qualifying offers Since oxygen is mainly transported by diffusion within tissue the oxygen pressure field reflects the local balance between oxygen supply and oxygen consumption and characterizes the state of oxygen supply Despite large physiological varia tions e g
Hydrogen sulfide and oxygen sensing implications in ~ Hypoxia of external or internal origin is a potential and recurring threat to all cells Vertebrates have developed complex and specialized oxygensensing tissues to monitor environmental hypoxia blood hypoxia hypoxemia and even local tissue hypoxia
JCI A PHD in immunosuppression oxygensensing pathways ~ Oxygensensing pathways in immune cells Tissue hypoxia and HIF activation occur following tissue injury infection inflammation and rapid tumor growth Resident or recruited immune cells must rapidly activate HIF to adapt and function in a hypoxic environment
Nobel Prize in medicine goes to oxygen sensing research ~ Nobel Prize in medicine goes to oxygen sensing research which showed that the vast majority of tissues share an oxygensensing mechanism Semenza went on to identify the hypoxiainducible
Cellular oxygen sensor system earns Nobel for trio Science ~ “How oxygen is sensed by both normal tissues and tumors is an incredibly important discovery that is highly deserving of a Nobel Prize” says Amato Giaccia a cancer researcher at Oxford In the 1980s biologists already knew that low oxygen levels in the body increase transcription of the gene for the hormone erythropoietin EPO in the kidney which in turn boosts production of oxygencarrying red blood cells
Noninvasive Oxygen Monitoring in ThreeDimensional Tissue ~ Oxygen gas levels found in the terminal vascular bed in tissues are about 8 5–10 but show differences between highly vascularized tissues such as bone ∼5–10 and bone marrow ∼2–7 or avascular tissues such as cartilage ∼1–6 Critical hypoxic levels
Ceramide Mediates Acute Oxygen Sensing in Vascular Tissues ~ Finally the role of nSMase in acute oxygen sensing was also observed in human PA and DA Innovation These data provide evidence for the proposal that nSMasederived ceramide is a critical player in acute oxygensensing in specialized vascular tissues
Product Cell Culture Flask with Integrated Oxygen Sensor ~ This plastic cell culture flask with integrated oxygen sensor is available for different growth areas It is delivered irradiated and precalibrated The CFSPSt3 can be read out with the SFR Shake Flask Reader or the SFR vario in combination with the TFlask Holder
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